RIG-I and other RNA sensors in antiviral immunity
Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens
MU Gack - Journal of virology, 2014 - Am Soc Microbiol
ABSTRACT RIG-I-like receptors (RLRs) play important roles in the host defense to
numerous viral pathogens. Since they were discovered, much light has been shed on the …
numerous viral pathogens. Since they were discovered, much light has been shed on the …
RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity
HJ Ramos, M Gale Jr - Current opinion in virology, 2011 - Elsevier
During virus infection, multiple immune signaling pathways are triggered, both within the
host cell and bystander cells of an infected tissue. These pathways act in concert to mediate …
host cell and bystander cells of an infected tissue. These pathways act in concert to mediate …
Antiviral RNA recognition and assembly by RLR family innate immune sensors
AM Bruns, CM Horvath - Cytokine & growth factor reviews, 2014 - Elsevier
Virus-encoded molecular signatures, such as cytosolic double-stranded or otherwise
biochemically distinct RNA species, trigger cellular antiviral signaling. Cytoplasmic proteins …
biochemically distinct RNA species, trigger cellular antiviral signaling. Cytoplasmic proteins …
RIGorous detection: exposing virus through RNA sensing
J Rehwinkel, C Reis e Sousa - Science, 2010 - science.org
Virus infection in mammals elicits a variety of defense responses that are initiated by signals
from virus-sensing receptors expressed by the host. These receptors include the …
from virus-sensing receptors expressed by the host. These receptors include the …
Regulation of RIG-I-like receptor signaling by host and viral proteins
JJ Chiang, ME Davis, MU Gack - Cytokine & growth factor reviews, 2014 - Elsevier
Vertebrate innate immunity is characterized by an effective immune surveillance apparatus,
evolved to sense foreign structures, such as proteins or nucleic acids of invading microbes …
evolved to sense foreign structures, such as proteins or nucleic acids of invading microbes …
RIG-I like receptors in antiviral immunity and therapeutic applications
RC Ireton, M Gale Jr - Viruses, 2011 - mdpi.com
The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense
mechanisms responsible for detecting viruses and triggering innate immune signaling …
mechanisms responsible for detecting viruses and triggering innate immune signaling …
[HTML][HTML] Viral evasion of intracellular DNA and RNA sensing
The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …
Toll‐like receptors, RIG‐I‐like RNA helicases and the antiviral innate immune response
AJV Thompson, SA Locarnini - Immunology and cell biology, 2007 - Wiley Online Library
The antiviral innate immune response follows the detection of viral components by host
pattern recognition receptors (PRRs). Two families of PRRs have emerged as key sensors of …
pattern recognition receptors (PRRs). Two families of PRRs have emerged as key sensors of …