Increasing diabetic population is one of the major health concerns all over the world.
Inhibition of α-glucosidase is a clinically proved and attractive strategy to manage diabetes …

Quantitative structure–activity relationships (QSAR) and molecular docking studies have
been performed on a series of 35 α-glucosidase inhibitory derivatives. The QSAR models …

Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors
shown a crucial importance in the treatment of this disease. Twenty oxindole based …

Diabetes mellitus (DM) is a chronic metabolic disease, the third killer of mankind. The finding
of potent drugs against diabetes remains challenging. In the present study, coumarin …

Xanthones and their derivatives have been reported to exhibit strong inhibitory activities
toward α-glucosidase. To provide deep insight into the correlation between inhibitory …

Diabetes is the most prevailing disease worldwide and emerged as the fourth leading cause
of mortality. Inhibition of intestinal a-Glucosidase enzyme is an effective approach for …

In developed countries and developing countries, obesity/overweight is considered a major
problem, in fact, it is now recognized as a major metabolic disorder. Additionally, obesity is …

Herein, we have built up structure–activity relationship (SAR), k-nearest neighbor, quantum
mechanical, field similarity analysis as well as a sufficient number of quantitative SAR …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemic state.
The α-glucosidase and α-amylase are considered two major targets for the management of …

Background Diabetes mellitus (DM) is one of the most defying health risk in the twenty-first
century promoting a high rate of morbidity and mortality that could possibly increase if no …