The T-cell antigen receptor (TCR) is a heterodimeric structure composed of highly variable a
and^ chains. Foreign antigens are presented to the TCR in the form of short peptides bound …

Bacterial and retroviral superantigens (SAGs) stimulate a high proportion of T cells
expressing specific variable regions of the T cell receptor (TCR) beta chain. Although most …

While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

CD4 T cell receptors (TCRs) recognize antigenic peptides presented by self major
histocompatibility complex (MHC) class II molecules as well as non-self MHC class II …

The interaction of the T-cell receptor (TCR) with peptide antigen plus major
histocompatibility complex (MHC) protein requires both alpha and beta chains of the TCR …

Bacterial superantigens such as Staphylococcus aureus enterotoxin A (SEA) are very potent
stimulators of T cells. They bind to the Vβ region of the TCR and to MHC class II, stimulating …

Superantigens (Sags) induce large-scale stimulation of T lymphocytes by a mechanism
distinct from conventional antigen presentation, involving direct MHC binding and …

Several studies have suggested that there is a direct interaction between the T cell receptor
(TCR) and the major histocompatibility complex (MHC) molecule during T cell recognition of …

Superantigen recognition by some T cells is strongly influenced by polymorphic residues of
the MHC class II molecule, suggesting that the TCR contacts the class II molecule during …

The binding of bacterial superantigens (SAgs) is profoundly affected by the nature of the
MHC class II-associated antigenic peptide. It was proposed that this limitation in the density …