Peroxisome proliferator-activated receptor α activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to …

T Banks, A Oyekan - Journal of hypertension, 2008 - journals.lww.com
Background Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent
nuclear transcription factors that regulate β-oxidation of fatty acids in various tissues. PPARα …

Antiinflammatory and antiarteriosclerotic effects of pioglitazone

M Ishibashi, K Egashira, K Hiasa, S Inoue, W Ni… - …, 2002 - Am Heart Assoc
Peroxisome proliferator-activated receptor-γ (PPARγ) ligands are widely used in patients
with insulin resistance and diabetes. Because coronary artery disease is a major …

RU486 antagonizes the inhibitory effect of peroxisome proliferator-activated receptor α on interleukin-6 production in vascular endothelial cells

X Xu, M Otsuki, S Sumitani, H Saito, H Kouhara… - The Journal of steroid …, 2002 - Elsevier
Peroxisome proliferator-acitivated receptor α (PPARα) is a member of nuclear receptor
superfamily. Recent studies have shown that the activators for PPARα inhibit the expression …

PPARα stimulation exerts a blood pressure lowering effect through different mechanisms in a time-dependent manner

L Ibarra-Lara, LG Cervantes-Pérez… - European journal of …, 2010 - Elsevier
Peroxisome proliferator activated receptors (PPARs) are a family of nuclear receptors that,
upon activation with selective ligands, work as transcription factors. Recently, these have …

[HTML][HTML] Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats

M Olukman, ED Sezer, S Ülker, EY Sözmen… - Journal of Diabetes …, 2010 - hindawi.com
Diabetic endothelial dysfunction is accompanied by increased oxidative stress and
upregulated proinflammatory and inflammatory mediators in the vasculature. Activation of …

[HTML][HTML] Peroxisome proliferator-activated receptor γ regulates angiotensin II-induced catalase downregulation in adventitial fibroblasts of rats

W Yang, J Zhang, H Wang, W Shen, P Gao, M Singh… - FEBS letters, 2011 - Elsevier
Peroxisome proliferator-activated receptor (PPAR) γ ligands oppose the effect induced by
angiotensin II (Ang II) to reduce oxidative stress and improve antioxidant status. In this study …

Modulation of cardiac and aortic peroxisome proliferator-activated receptor-γ expression by oxidative stress in chronically glucose-fed rats

A El Midaoui, L Wu, R Wang… - American journal of …, 2006 - academic.oup.com
Background: The aim of the present study was to examine the chronic effects of α-lipoic acid
on proliferator peroxisome activated receptors-γ (PPAR-γ) and PPAR-α expressions in …

The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox …

I Inoue, S Goto, T Matsunaga… - Metabolism …, 2001 - metabolismjournal.com
We examined the effects of a variety of ligands/activators of the peroxisome proliferator-
activated receptor (PPAR) on the expression of the superoxide scavenger enzyme, Cu 2+ …

PPARα activator effects on Ang II–induced vascular oxidative stress and inflammation

QN Diep, F Amiri, RM Touyz, JS Cohn, D Endemann… - …, 2002 - Am Heart Assoc
Docosahexaenoic acid (DHA), a peroxisome proliferator–activated receptor-α (PPARα)
activator, reduces blood pressure (BP) in some hypertensive models by unclear …

Peroxisome proliferator-activated receptor gamma mediated inhibition of plasminogen activator inhibitor type 1 production and proliferation of human umbilical vein …

HK Hong, YM Cho, KH Park, CT Lee, HK Lee… - Diabetes research and …, 2003 - Elsevier
Insulin resistance and diabetes mellitus promote the atherosclerotic process, where an
endothelial dysfunction plays a key role. The diabetic milieu elevates the production of the …