Regulation of Peroxisome Proliferator–Activated Receptor-γ by Angiotensin II Via Transforming Growth Factor-β1–Activated p38 Mitogen-Activated Protein Kinase in …
V Subramanian, J Golledge, EB Heywood… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Peroxisome proliferator–activated receptor-γ (PPARγ) ligands attenuate
angiotensin II (Ang II)–induced atherosclerosis through interactions with vascular smooth …
angiotensin II (Ang II)–induced atherosclerosis through interactions with vascular smooth …
Peroxisome Proliferator–Activated Receptor-γ Ligands Inhibit Nitric Oxide Synthesis in Vascular Smooth Muscle Cells
U Ikeda, M Shimpo, Y Murakami, K Shimada - Hypertension, 2000 - Am Heart Assoc
Peroxisome proliferator–activated receptor-γ (PPARγ) is a key player in glucose metabolism.
If PPARγ ligands modulate nitric oxide (NO) synthesis in the vascular tissue, they may affect …
If PPARγ ligands modulate nitric oxide (NO) synthesis in the vascular tissue, they may affect …
Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator–activated receptor-γ activators
V Pasceri, HD Wu, JT Willerson, ETH Yeh - Circulation, 2000 - Am Heart Assoc
Background—Peroxisome proliferator–activated receptor-γ (PPARγ) is expressed in
atherosclerotic plaques and in endothelial cells. The possible effects of PPARγ activators on …
atherosclerotic plaques and in endothelial cells. The possible effects of PPARγ activators on …
Wy14643 improves vascular function in the aorta of the spontaneously hypertensive rat mainly by activating peroxisome proliferator-activated receptors alpha
C Qu, SWS Leung, PM Vanhoutte, RYK Man - European journal of …, 2012 - Elsevier
Experiments were designed to determine if Wy14643 ([[4-chloro-6-[(2, 3-dimethylphenyl)
amino]-2-pyrimidinyl] thio]-acetic acid), a preferential agonist at peroxisome proliferator …
amino]-2-pyrimidinyl] thio]-acetic acid), a preferential agonist at peroxisome proliferator …
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene
LV d'Uscio, T He, AVR Santhanam… - American Journal …, 2014 - journals.physiology.org
Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear hormone receptor that is
mainly involved in lipid metabolism. Recent studies have suggested that PPAR-δ agonists …
mainly involved in lipid metabolism. Recent studies have suggested that PPAR-δ agonists …
Role of peroxisome proliferator-activated receptor β agonist on angiogenesis in hindlimb ischemic diabetic rats
INTRODUCTION: Studies indicated that PPARβ agonists play a role in modulation of
angiogenesis. In this study, we evaluated the effect of specific PPARβ agonist, GW0742, on …
angiogenesis. In this study, we evaluated the effect of specific PPARβ agonist, GW0742, on …
Peroxisome proliferator-activated receptor γ ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor γ …
JA Polikandriotis, LJ Mazzella… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—We recently reported that the peroxisome proliferator-activated receptor γ
(PPARγ) ligands 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2) and ciglitazone increased …
(PPARγ) ligands 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2) and ciglitazone increased …
Synergistic vascular protective effects of combined low doses of PPARα and PPARγ activators in angiotensin II‐induced hypertension in rats
C De Ciuceis, F Amiri, M Iglarz, JS Cohn… - British journal of …, 2007 - Wiley Online Library
Background and Purpose: Protective cardiovascular effects of peroxisome proliferator
activated receptor (PPAR) α and PPARγ activators have been demonstrated. If used as …
activated receptor (PPAR) α and PPARγ activators have been demonstrated. If used as …
The Peroxisome Proliferator‐Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting …
D Zhang, Y Wang, M Yi, S Zhang… - Cardiology Research and …, 2020 - Wiley Online Library
Objective. Hypercholesterolemia‐(HC‐) induced endothelial dysfunction is the first step of
atherogenesis, and the peroxisome proliferator‐activated receptor γ (PPARγ) has been …
atherogenesis, and the peroxisome proliferator‐activated receptor γ (PPARγ) has been …
Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats
T Matsumoto, E Noguchi, T Kobayashi… - Free Radical Biology and …, 2007 - Elsevier
The objectives of this study were to determine the effects of chronic treatment with
pioglitazone, a peroxisome proliferator-activated receptor γ agonist, on the impaired …
pioglitazone, a peroxisome proliferator-activated receptor γ agonist, on the impaired …