Objective. We sought to investigate whether the peroxisome proliferator-activated receptor-γ
(PPAR-γ) ligand pioglitazone can attenuate vascular fibrosis in spontaneously hypertensive …

2665 PPARγ, PPARδ and Vascular Diseases inhibits the response of VSMC to inflammatory
stimuli. Tumor necrosis factor alpha (TNFα)-induced expression of chemokines VCAM-1 …

Objective—Peroxisome proliferator–activated receptors (PPARs) may modulate in vitro the
vascular production of vasoactive peptides such as endothelin-1 (ET-1). Thus, we …

Aims: Hypertension is associated with increased plasma inflammatory markers such as
cytokines and increased vascular cyclooxygenase-2 (COX-2) expression. The ability of …

Peroxisome proliferator-activated receptors (PPARs) regulate the vascular cell functions as
well as systemic lipid and glucose metabolism. Here, we studied the effect of TAK-559, a …

Peroxisome proliferator-activated receptor-alpha (PPAR-α) is a key regulator of lipid and
glucose metabolism and has been implicated in inflammation. The vascular effects of …

Peroxisome proliferator-activated receptor γ (PPARγ) activation has anti-angiogenic and
apoptotic effects in endothelial cells. Here, we investigated the mechanisms of the anti …

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor β/δ
(PPARβ) has been shown to improve insulin resistance and plasma high-density lipoprotein …

Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are ligand-activated
transcription factors belonging to the nuclear receptor superfamily. PPARα has effects on …

Aim: Peroxisome proliferator activated receptors (PPARs) are nuclear transcription factors
that regulate numerous genes influencing blood pressure. The aim of this study was to …