3D QSAR and Docking Studies of Various Amido and Benzyl-substituted 3-amino-4-(2-cyanopyrrolidide) pyrrolidinyl Analogs as DPP-IV Inhibitors
R Agrawal, P Jain, S Narayan Dikshit… - Protein and Peptide …, 2013 - ingentaconnect.com
The article describes the development of a robust pharmacophore model and the
investigation of structure activity relationship analysis of 3-amino-4-(2-cyanopyrrolidide) …
investigation of structure activity relationship analysis of 3-amino-4-(2-cyanopyrrolidide) …
Atom-based 3D-QSAR and Docking Studies of Various 3-aminomethyl-1, 2-dihydro-4-phenyl-1-isoquinolones Derivatives as an Effective DPP-IV Inhibitors and its …
R Agrawal, P Jain, S Narayan Dikshit… - … & Metabolic Agents …, 2013 - ingentaconnect.com
The article describes development of a robust pharmacophore model and investigates
structure activity relationship of 3-aminomethyl-1, 2-dihydro-4-phenyl-1-isoquinolone …
structure activity relationship of 3-aminomethyl-1, 2-dihydro-4-phenyl-1-isoquinolone …
3D QSAR and docking study of gliptin derivatives as DPP-IV inhibitors
R Agrawal, P Jain, SN Dikshit… - … Chemistry & High …, 2013 - ingentaconnect.com
The article describes the development of a robust pharmacophore model and the
investigation of structure activity relationship analysis of 46 xanthine derivatives reported for …
investigation of structure activity relationship analysis of 46 xanthine derivatives reported for …
[HTML][HTML] 3D-QSAR and docking studies of arylmethylamine-based DPP IV inhibitors
C Jiang, S Han, T Chen, J Chen - Acta Pharmaceutica Sinica B, 2012 - Elsevier
The present work was focused on the study of the three-dimensional (3D) structural
requirements for the highly potent bioactivity of dipeptidyl peptidase (DPP) IV's inhibitor. At …
requirements for the highly potent bioactivity of dipeptidyl peptidase (DPP) IV's inhibitor. At …
Phenanthridine sulfonamide derivatives as potential DPP-IV inhibitors: design, synthesis and biological evaluation
RA Khalaf, S Alqazaqi, M Aburezeq… - … -Aided Drug Design, 2022 - ingentaconnect.com
Background: Diabetes mellitus is a chronic metabolic disorder, characterized by
hyperglycemia over a prolonged period, disturbance of fat, protein, and carbohydrate …
hyperglycemia over a prolonged period, disturbance of fat, protein, and carbohydrate …
QSAR, Docking and Molecular Fragment Replacement Study based on a Conformation-Independent Approach on Trifluorophenyl β-aminoamide derivatives as DPP …
P Swaraj, S Rajesh - Current Enzyme Inhibition, 2017 - ingentaconnect.com
Background: Inhibition of Dipeptidyl peptidase IV (DPP IV) enzyme is an attractive and
appropriate target for the treatment of type 2 diabetes. In order to discover for potent DPP IV …
appropriate target for the treatment of type 2 diabetes. In order to discover for potent DPP IV …
Hybrid docking-QSAR studies of DPP-IV inhibition activities of a series of aminomethyl-piperidones
Z Amini, MH Fatemi, S Gharaghani - Computational Biology and Chemistry, 2016 - Elsevier
In this study, the dipeptidyl peptidase-IV (DPP-IV) inhibition activities of a series of novel
aminomethyl-piperidones were investigated by molecular docking studies and modeled by …
aminomethyl-piperidones were investigated by molecular docking studies and modeled by …
3D-QSAR, in vitro assay and MD simulations studies on the design, bioactivities and different inhibitory modes of the novel DPP-IV inhibitory peptides
Z Liang, H Li, X Lu, G Lin, Y Li, R Zhang - Journal of Molecular Structure, 2023 - Elsevier
Abstract 3D-QSAR, in vitro assay and molecular dynamic simulations were adopted to
investigate the DPP-IV inhibitory peptides and its molecular mechanism. A CoMFA model (Q …
investigate the DPP-IV inhibitory peptides and its molecular mechanism. A CoMFA model (Q …
[PDF][PDF] Ligand Based in-silico Study on pyridopyrimidinedione derivatives as dipeptidyl peptidase-IV inhibitors
G Piyush, JS Kumar - Indian J Pharm Edu Res, 2017 - ijper.org
Background: Type-2 diabetes mellitus can be effectively treated with dipeptidyl peptidase-IV
inhibitors. Diverse classes of molecules have exhibited promising DPP-IV inhibition …
inhibitors. Diverse classes of molecules have exhibited promising DPP-IV inhibition …
3D QSAR Study and Designing of Novel Prolinenitriles Derivatives as Dipeptidyl Peptidase IV Inhibitor
The QSAR study was performed on 21 derivatives of 4-substituted prolyl prolinenitriles using
kNN-MFA method. The stepwise, genetic algorithm and simulated annealing was used for …
kNN-MFA method. The stepwise, genetic algorithm and simulated annealing was used for …