Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Background The prevalence of type 2 diabetes is rapidly increasing world-wide and insulin
resistance is central to the aetiology of this disease. The biology underpinning the …

Multiple organs contribute to the development of peripheral insulin resistance, with the major
contributors being skeletal muscle, liver, and adipose tissue. Because insulin resistance …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

The prevalence of type 2 diabetes mellitus (DM2) is increasing precipitously as a
consequence of the aging population and obesity epidemic. Type 2 diabetes mellitus is …

The mechanism (s) behind the decreased ability of insulin to facilitate glucose uptake in
insulin sensitive tissues as seen in type 2 diabetes is not resolved. With the rapidly …

Reduced mitochondrial capacity in skeletal muscle has been suggested to underlie the
development of insulin resistance and type 2 diabetes mellitus (T2DM). However, data …

While impairments in peripheral tissue insulin signalling have a well-characterized role in
the development of insulin resistance and type 2 diabetes (T2D), the specific mechanisms …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …