Abundant evidence has been accumulated to suggest that mitochondrial dysfunction is
associated with type 2 diabetes. Research findings from this and other laboratories have …

Mitochondrial dysfunction has been associated with insulin resistance, obesity and diabetes.
Hyperinsulinaemia and hyperlipidaemia are hallmarks of the insulin-resistant state. We …

Significance: Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus
(T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Mitochondria within skeletal muscle have been implicated in insulin resistance of obesity
and type 2 diabetes mellitus as well as impaired muscle function with normal aging …

Insulin resistance is one of the earliest pathological features of a suite of diseases including
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …

Insulin resistance plays a major role in the pathogenesis of the metabolic syndrome and
type 2 diabetes, and yet the mechanisms responsible for it remain poorly understood …

Insulin resistance is characterized by hyperglycaemia, dyslipidaemia and oxidative stress
prior to the development of type 2 diabetes mellitus. To date, a number of mechanisms have …

Skeletal muscle insulin resistance in obesity associates with mitochondrial dysfunction, but
the causality of this association is controversial. This review evaluates mitochondrial models …