Mitochondria are essential for intermediary metabolism as well as energy production in the
cell. Their aerobic metabolism permits oxidation of glucose and fatty acids for the generation …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

Insulin resistance in skeletal muscle is a prominent feature of obesity and type 2 diabetes.
The association between mitochondrial changes and insulin resistance is well known. More …

Obesity, insulin resistance, type 2 diabetes mellitus, and aging are associated with impaired
skeletal muscle oxidation capacity, reduced mitochondrial content, and lower rates of …

Human mitochondria can be studied either in biopsies or by measuring flux through ATP
synthase and phosphocreatine recovery using magnetic resonance spectroscopy …

Mitochondria play a key role in energy metabolism in many tissues, including skeletal
muscle and liver. Inherent disorders of mitochondria such as DNA deletions cause major …

Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the
development of insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial …

The traditional view of mitochondria as isolated, spherical, energy producing organelles, is
undergoing a revolutionary change. Emerging data show that mitochondria form a dynamic …

Relationships between insulin action and oxidative capacity in skeletal muscle have been
suggested in humans, particularly in insulin-resistance-related metabolic disorders, such as …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …