Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes and an early
detectable abnormality in the development of this disease. The cellular mechanisms of …

This study sought to elucidate the relationship between skeletal muscle mitochondrial
dysfunction, oxidative stress, and insulin resistance in two mouse models with differential …

Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …

Diet, energy metabolism and mitochondrial biogenesis : Current Opinion in Clinical Nutrition &
Metabolic Care Diet, energy metabolism and mitochondrial biogenesis : Current Opinion in …

Aims/hypothesis Muscle mitochondrial function can vary during fasting, but is lower during
hyperinsulinaemia in insulin-resistant humans. Ageing and hyperlipidaemia may be the …

Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high
levels of circulating free fatty acids (FFAs). The latter is known to cause insulin resistance, in …

Background Although mounting evidence indicates that insulin resistance (IR) co‐occurs
with mitochondrial dysfunction in skeletal muscle, there is no clear causal link between …

Background Mitochondria are the main cellular sites devoted to ATP production and lipid
oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of …

Mitochondria play a key role in energy metabolism and ATP production in many tissues,
including skeletal muscle, cardiac muscle, brain and liver. Inherent disorders of …

Context: In obesity, skeletal muscle insulin resistance may be associated with smaller
mitochondria. Objective: Our objective was to examine the effect of a lifestyle-modification …