Therapeutic modulation of autophagy: which disease comes first?

MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
The relentless efforts of thousands of researchers have allowed deciphering the molecular
machinery that regulates and executes autophagy, thus identifying multiple molecular …

[HTML][HTML] Autophagy and disease

A Thorburn - Journal of biological chemistry, 2018 - ASBMB
As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …

Aberrant regulation of autophagy in mammalian diseases

W Xie, J Zhou - Biology letters, 2018 - royalsocietypublishing.org
Autophagy is a major cellular metabolic pathway that facilitates degradation of a subset of
long-lived proteins and cytoplasmic organelles in eukaryotic cells. This pathway plays a vital …

[HTML][HTML] Autophagy in the pathogenesis of disease

B Levine, G Kroemer - Cell, 2008 - cell.com
Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation,
development, and homeostasis. Autophagy principally serves an adaptive role to protect …

[HTML][HTML] Autophagy: a druggable process that is deregulated in aging and human disease

G Kroemer - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …

Autophagy—from molecular mechanisms to clinical relevance

M Lippai, Z Szatmári - Cell biology and toxicology, 2017 - Springer
Autophagy is a lysosomal degradation pathway of eukaryotic cells that is highly conserved
from yeast to mammals. During this process, cooperating protein complexes are recruited in …

Therapeutic targeting of autophagy in disease: biology and pharmacology

Y Cheng, X Ren, WN Hait, JM Yang - Pharmacological reviews, 2013 - ASPET
Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …

Autophagy: a druggable process

E Morel, M Mehrpour, J Botti, N Dupont… - Annual Review of …, 2017 - annualreviews.org
Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …

[HTML][HTML] Autophagy for the avoidance of degenerative, inflammatory, infectious and neoplastic disease

G Kroemer, E White - Current opinion in cell biology, 2010 - ncbi.nlm.nih.gov
Macroautophagy (henceforth referred to as autophagy) is a process conserved from yeast to
man for the identification, collection and degradation of cellular components including …

Autophagy and disease: unanswered questions

Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …