Sarcopenia—consequences, mechanisms, and potential therapies

LJS Greenlund, KS Nair - Mechanisms of ageing and development, 2003 - Elsevier
Increasingly, the worldwide population is growing older. Sarcopenia occurs with age and is
characterized by loss of muscle mass, strength and endurance. Mechanisms that underlie …

Reactive oxygen species in sarcopenia: Should we focus on excess oxidative damage or defective redox signalling?

MJ Jackson - Molecular aspects of medicine, 2016 - Elsevier
Physical frailty in the elderly is driven by loss of muscle mass and function and hence
preventing this is the key to reduction in age-related physical frailty. Our current …

Sarcopenia of aging and its metabolic impact

H Karakelides, KS Nair - Current topics in developmental biology, 2005 - Elsevier
Sarcopenia contributes significantly to the morbidity, decrease in quality of life, and health
care costs in the elderly. It is characterized by a decrease in muscle mass and strength …

Sarcopenia: effects on body composition and function

R Roubenoff - The Journals of Gerontology Series A: Biological …, 2003 - academic.oup.com
Sarcopenia is the loss of muscle mass that happens to everyone with age. However, the rate
of sarcopenia and the severity of its sequelae vary greatly according to health status …

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

J Angulo, M El Assar, L Rodriguez-Manas - Molecular aspects of medicine, 2016 - Elsevier
Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

Sarcopenia: an overview

E Marzetti, R Calvani, M Tosato, M Cesari… - Aging clinical and …, 2017 - Springer
Sarcopenia, the age-dependent loss of muscle mass and function, is a common condition
among older adults, and is associated with several adverse health outcomes. Owing to the …

Sarcopenia: etiology, nutritional approaches, and miRNAs

R Cannataro, L Carbone, JL Petro, E Cione… - International Journal of …, 2021 - mdpi.com
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …

Sarcopenia, frailty and their prevention by exercise

CM Nascimento, M Ingles, A Salvador-Pascual… - Free Radical Biology …, 2019 - Elsevier
Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

Sarcopenia–The search for emerging biomarkers

A Kalinkovich, G Livshits - Ageing research reviews, 2015 - Elsevier
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the life quality of elder people. In view of increasing life expectancy, sarcopenia …

Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction

E Marzetti, H Anne Lees, S Eva Wohlgemuth… - Biofactors, 2009 - Wiley Online Library
Sarcopenia, the loss of muscle mass and function, is a common feature of aging and impacts
on individual health and quality of life. Several cellular mechanisms have been involved in …