Cytochromes P450 are members of a superfamily of hemoproteins that catalyze a variety of
oxidative reactions in the metabolism of endogenous and exogenous hydrophobic …

The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …

Genetic variation has a significant impact on an individual's metabolism and response to a
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …

Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of
pharmacokinetic variability in human. Although the poor metabolizer phenotype is known to …

CYP2D6 is of great importance for the metabolism of clinically used drugs and about 20–
25% of those are metabolised by this enzyme. In addition, the enzyme utilises …

The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly
used medications. Variation in CYP2D6 is associated with inter-individual differences in …

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Information on genetic variation in the cytochrome P450 (CYP) genes is maintained in the
Human Cytochrome P450 Allele (CYP-allele) Nomenclature Database (http://www …

Methods This article reviews the information derived from various studies over the past
decade and explains the molecular basis of functional differences in CYP2D6 variants …

CYP2D6 is a highly polymorphic enzyme that mediates the metabolism of around 20% of all
currently prescribed drugs. Genetic variability within CYP2D6 results in poor (PM) …