Background: Duloxetine and amitriptyline are antidepressants used in the treatment of
fibromyalgia. In published systematic reviews, there is no agreement about which drug is …

Background Duloxetine has been studied in four distinct chronic pain conditions–
osteoarthritis (OA), fibromyalgia, chronic low back pain (CLBP) and diabetic peripheral …

Background: While emotional symptoms such as depressed mood and loss of interest have
traditionally been considered to constitute the core symptoms of major depressive disorder …

Importance Amitriptyline is an established medication used off-label for the treatment of
fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological …

Background: Pain is common in multiple sclerosis (MS). Duloxetine has a potential
therapeutic role in treating MS-related pain. Methods: Thirty-eight MS patients were …

Background: Depression is a chronic disease consisting of emotional/psychological and
physical symptoms. Emotional symptoms have been shown to respond to currently available …

Background Patients with multiple sclerosis (MS) often report neuropathic pain (NP‐MS).
The purpose of this study was to assess the efficacy and tolerability of duloxetine as …

The evidence that the effects of the antidepressant duloxetine on painful physical symptoms
in depression and chronic pain disorders are a direct analgesic effect rather than an indirect …

Objective. To investigate the relationship between changes in clinical rating scale items and
endpoint Patient Global Impression of Improvement (PGI-I). Methods. Data were pooled from …

Background: Despite treatment advances, major depressive disorder (MDD) is still a
significant cause of morbidity and mortality. Current therapies frequently fall short of …