We studied the pedigrees of 17 index patients with osteosarcoma, recording malignant
disease and cause of death for first-and second-degree relatives. There were seven cancers …

BACKGROUND Second malignant neoplasms have been noted infrequently in survivors of
osteosarcoma treated before 1970. METHODS For the above reason, the authors surveyed …

Several familial cancer syndromes have been identified. The syndrome of sarcomas, breast
cancer and other neoplasms, known as Li‐Fraumeni syndrome, is characterized by several …

Family history of cancer and features of the Li-Fraumeni syndrome (LFS) were investigated
in 42 patients with soft tissue sarcoma or osteosarcoma in a pediatric hospital in Mexico City …

In 1969 Li and Fraumeni identified, from a systematic study of 648 children with
rhabdomyosarcomas, five families in which a sibling or a cousin was affected by sarcoma (Li …

Background Recent studies have identified germline mutations of the p53 tumor-suppressor
gene in families with the Li—Fraumeni syndrome, a rare inherited disorder characterized by …

Genetic anticipation is the increased incidence, earlier onset, or increased severity of a
disease in successive generations. Before the biological basis of anticipation had been …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives
of children with bone or soft tissue sarcomas is described. It is proposed that germ cell …

Two recent reports have described inherited mutations in p53 associated with the
predisposition to develop early cancers (Malkin et al., 1990; Srivastava et al., 1990). These …