Objectives. To evaluate the inflammatory status and the cartilage regenerative potential of
pathological synovial fibroblasts from patients with osteoarthritis (OA) compared with non …

Objective The differentiation of mesenchymal stem cells (MSCs) into chondrocytes provides
an attractive basis for the repair and regeneration of articular cartilage. Under clinical …

Background The aim of the study was to characterize synovial cells from OA synovium with
low-grade and moderate-grade synovitis and to define the role of synovial macrophages in …

Objective To investigate whether articular chondrocytes from rheumatoid arthritis (RA)
patients have acquired a proinflammatory phenotype. Method Articular cartilage explants …

We investigated the effects of CD14 macrophages and proinflammatory cytokines on
chondrogenic differentiation of osteoarthritic synovium-derived stem cells (SDSCs) …

Objective To assess the chondrogenic potential of cells within the synovium. Methods
Explants of synovium taken from various sites in the joint were embedded in agarose and …

Autologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up
studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is …

Introduction Autologous chondrocyte transplantation (ACT) is a routine technique to
regenerate focal cartilage lesions. However, patients with osteoarthritis (OA) are lacking an …

Introduction Activated synovial fibroblasts are thought to play a major role in the destruction
of cartilage in chronic, inflammatory rheumatoid arthritis (RA). However, profound insight into …

Background aims Synovial mesenchymal stem cells (MSCs) are an attractive cell source for
cartilage regeneration because of their high proliferative ability and chondrogenic potential …