Hepatic fibrosis (HF) is a wound-healing response that occurs during chronic liver injury and
features by an excessive accumulation of extracellular matrix (ECM) components. Activation …

Hepatic fibrosis is the common wound‐healing response to chronic liver injury. In this
process, activation of hepatic stellate cells is characteristic of cell proliferation and migration …

Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …

Hepatic fibrogenesis is characterized by activation of hepatic stellate cells (HSCs) and
accumulation of extracellular matrix (ECM). The impact of ECM on TGF-β-mediated …

Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced,
fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing …

Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are
the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative …

Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due
to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Current anti-fibrotic effect of antioxidants in vivo is disappointing due probably to the fact that
once liver fibrogenesis is established it is too advanced to be reversed by anti-oxidation …

The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …