Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Despite co-evolving with humans for centuries and being intensely studied for decades, the
immune correlates of protection against Mycobacterium tuberculosis (Mtb) have yet to be …

With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …

Highlights•Much is unclear about protective CD4 T cell responses against Mycobacterium
tuberculosis.•Th1 responses are essential but other effector mechanisms also protect …

There are more cases of tuberculosis in the world today than at any other time in history. The
global epidemic has generated intense interest into the immunological mechanisms that …

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the coordinated
efforts of innate and adaptive immune cells. Diverse pulmonary myeloid cell populations …

The continuing HIV/AIDS epidemic and the spread of multi-drug resistant Mycobacterium
tuberculosis has led to the perpetuation of the worldwide tuberculosis epidemic. While M …

CD4 T cells are critical for protective immunity against Mycobacterium tuberculosis (Mtb), the
cause of tuberculosis (TB). Yet to date, TB vaccine candidates that boost antigen-specific …

Containment of Mycobacterium tuberculosis (Mtb) infection requires T cell recognition of
infected macrophages. Mtb has evolved to tolerate, evade, and subvert host immunity …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most important
infectious diseases globally. Immune effector mechanisms that lead to protection or …