Targeted metabolomics has significant advantages for quantification but suffers from
reduced metabolite coverage. In this study, we developed a large-scale targeted …

Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Metabolomics is a strategy for analysis, and quantification of the complete collection of
metabolites present in biological samples. Metabolomics is an emerging area of scientific …

The advancement of mass spectrometry-based analytical platform largely facilitates small-
molecule metabolomics studies, which allows simultaneously analysis of a large number of …

The metabolome is the terminal downstream product of the genome and consists of the total
complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or …

Purpose The aim of the project was to apply ultra-high-performance liquid chromatography–
quadrupole-Orbitrap-high-resolution mass spectrometry for serum metabolite profiling of non …

Background Non-targeted metabolomics based on mass spectrometry enables high-
throughput profiling of the metabolites in a biological sample. The large amount of data …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

The potential of a metabolomics method to detect statistically significant perturbations in the
metabolome of an organism is enhanced by excellent analytical precision, unequivocal …