Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …

Despite improvements in the understanding of disease biology, pancreatic ductal
adenocarcinoma (PDAC) remains the most malignant cancer of the pancreas. PDAC …

The tumor microenvironment (TME) is known to direct cancer cell growth, migration, invasion
into the matrix and distant tissues, and to confer drug resistance in cancer cells. While …

Cancer progression is closely related to changes in the structure and mechanical properties
of the tumor microenvironment (TME). In many solid tumors, including pancreatic cancer, the …

Breast cancer is one of the leading cancer forms affecting females worldwide.
Characterizing the mechanical properties of breast cancer tissue is important for diagnosis …

Pancreatic cancer exhibits a unique bioarchitecture and desmoplastic cancer-stoma
interplay that governs disease progression, multi-resistance, and metastasis. Emulating the …

Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …

Pancreatic ductal adenocarcinomas (PDAC) is one of the stiffest malignancies with strong
solid stresses. Increasing stiffness could alter cellular behavior and trigger internal signaling …

The stiffness of tumors and their host tissues is much higher than most hydrogels, which are
conventionally used to study in vitro cancer progression. The tumoroid assay is an …