The hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α) have extensive structural
homology and have been identified as key transcription factors responsible for gene …

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factors
(HIFs), HIF-1α and HIF-2α. The HIF-1α and HIF-2α subunits are structurally similar in their …

Cellular integrity in hypoxia is dependent on molecular adaptations dominated by the
heterodimeric transcription factor hypoxia-inducible factor (HIF). The HIF complex contains …

Hypoxia-inducible factor-1 (HIF-1), the master regulator of transcriptional responses to
reduced oxygen tension (hypoxia) in mammalian cells, consists of one HIF-1α and one HIF …

HIF (hypoxia-inducible factor)-3α is the third member of the HIF transcription factor family.
Whereas HIF-1α and-2α play critical roles in the cellular and systemic adaptation to hypoxia …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …

Hypoxia-inducible factors (HIFs) play key roles in the cellular response to hypoxia. It is
widely accepted that whereas HIF-1 and HIF-2 function as transcriptional activators, HIF-3 …

The basic helix-loop-helix-Per-ARNT-Sim–proteins hypoxia-inducible factor (HIF)-1α and
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …

The role of the hypoxia-inducible factor (HIF) subunits 1α and 2α in response to hypoxia is
well established in lung epithelial cells, whereas little is known about HIF-3α with respect to …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …