Introduction Identification of gene expression-based breast cancer subtypes is considered a
critical means of prognostication. Genetic mutations along with epigenetic alterations …

Introduction Breast cancer is a heterogeneous disease, with several intrinsic subtypes
differing by hormone receptor (HR) status, molecular profiles, and prognosis. However, the …

Introduction Five different molecular subtypes of breast cancer have been identified through
gene expression profiling. Each subtype has a characteristic expression pattern suggested …

Breast cancer is a heterogeneous disease that can be divided in subtypes based on
histology, gene expression profiles as well as differences in genomic aberrations. Distinct …

In cancer, epigenetic states are deregulated and thought to be of significance in cancer
development and progression. We explored DNA methylation-based signatures in …

Tumour heterogeneity is an obstacle to effective breast cancer diagnosis and therapy. DNA
methylation is an important regulator of gene expression, thus characterizing tumour …

The diversity of breast cancers reflects variations in underlying biology and affects the
clinical implications for patients. Gene expression studies have identified five major …

Background Aberrant DNA methylation is frequently observed in breast cancer. However,
the relationship between methylation patterns and the heterogeneity of breast cancer has …

Aim: To provide a breast cancer (BC) methylotype classification by genome-wide CpG
islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation …

Background DNA methylation regulates gene expression, through the inhibition/activation of
gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can …