Purpose Gene-specific methylation and expression have shown biological and clinical
importance for breast cancer diagnosis and prognosis. Integrated analysis of gene …

Abstract Introduction Aberrant methylation of CpG islands is a hallmark of cancer and occurs
at an early stage in breast tumorigenesis. However, its impact on tumor development is not …

Background: Hundreds of hypermethylated genes have been described in breast cancer, yet
the nature and contribution of these genes in their methylated state to overall risk and …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …

Recent data have revealed that epigenetic alterations, including DNA methylation and
chromatin structure changes, are among the earliest molecular abnormalities to occur during …

It is now understood that epigenetic alterations occur frequently in sporadic breast
carcinogenesis, but little is known about the epigenetic alterations associated with familial …

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …

Aberrant DNA methylation is a key feature of breast carcinoma. We aimed to test the
association between breast cancer risk and epigenome-wide methylation in DNA from …

Although DNA methylation profiles in breast cancer have been connected to breast cancer
molecular subtype, there have been no studies of the association of DNA methylation with …

Breast cancer (BC) is a disease with diverse tumor heterogeneity, which challenges
conventional approaches to develop biomarkers for early detection and prognosis. To …