The complement system, an important part of the innate immune system, provides protection
against invading pathogens, in part through its proinflammatory activities. Although most …

Complement is part of the innate immune system that plays a major role in the initiation of
inflammation and host defence against pathogenic bacteria. Complement activation is also a …

Through its involvement in inflammation, opsonization, and cytolysis, the complement
protects against infectious agents. Although most of the complement proteins are …

The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor
with a range of immune modulatory functions. C3aR is activated by the third complement …

The complement system is a pivotal component of the innate immune system which protects
the host from infection and injury. Complement proteins can be induced in all cell types …

Complement is an essential component of inflammation that plays a role in ischemic brain
injury. Recent reports demonstrate novel functions of complement in normal and diseased …

Astrocytes perform a range of homeostatic and regulatory tasks that are critical for normal
functioning of the central nervous system. In response to an injury or disease, astrocytes …

The complement system of innate immunity is emerging as a novel player in
neurodevelopmental processes. The receptor for C3a, C3aR, shares a close evolutionary …

Complement is implicated in the pathogenesis of inflammatory disorders of the central
nervous system (CNS), like multiple sclerosis, Alzheimer's disease, and trauma. The …

The C3aR is expressed throughout the CNS and is increased in expression on glial cells
during CNS inflammation. However, the role that C3a and the C3aR play in chronic …