Lymphoid enhancer factor (LEF1), a nuclear mediator of Wnt signaling, is required for the
formation of organs that depend on inductive interactions between epithelial and …

LEF1 is a cell-type-specific transcription factor and mediates Wnt signaling pathway by
association with its co-activator β-catenin. Wnt signaling is known to be critical for the …

Targeted inactivation of the murine gene encoding the transcription factor LEF-1 abrogates
the formation of organs that depend on epithelial-mesenchymal tissue interactions. In this …

Classical tissue recombination studies demonstrated that initiation of tooth development
depends on activation of odontogenic potential in the mesenchyme by signals from the …

Tooth development is initiated by signals from the oral ectoderm which induce gene
expression required for tooth development in the underlying mesenchyme. In this study, we …

Ectodermal dysplasia syndromes affect the development of several organs, including hair,
teeth, and glands. The recent cloning of two genes responsible for these syndromes has led …

In this review, we discuss the central role of fibroblast growth factor (FGF) signaling in
mammalian tooth development. The FGF family consists of 22 members, most of which bind …

The morphogenesis and cell differentiation in developing teeth is governed by interactions
between the oral epithelium and neural crest‐derived ectomesenchyme. The fibroblast …

Members of the LEF-1/TCF family of transcription factors have been implicated in the
transduction of Wnt signals. However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the …

Rodent incisors regenerate throughout the lifetime of the animal owing to the presence of
epithelial and mesenchymal stem cells in the proximal region of the tooth. Enamel, the …