Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families
CV Broeckhoven, AM Genthe, A Vandenberghe… - Nature, 1987 - nature.com
The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
A Goate, MC Chartier-Harlin, M Mullan, J Brown… - Nature, 1991 - nature.com
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene
RE Tanzi, PHS George-Hyslop, JL Haines, RJ Polinsky… - Nature, 1987 - nature.com
Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
RE Tanzi, AI McClatchey, ED Lamperti… - Nature, 1988 - nature.com
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
MC Chartier-Harlin, F Crawford, H Houlden, A Warren… - Nature, 1991 - nature.com
A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
J Kang, HG Lemaire, A Unterbeck, JM Salbaum… - Nature, 1987 - nature.com
Alzheimer's disease1 is characterized by a widespread functional disturbance of the human
brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles2 and …
brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles2 and …
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
P Seubert, T Oltersdorf, MG Lee, R Barbour… - Nature, 1993 - nature.com
THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …
Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease
CL Joachim, H Mori, DJ Selkoe - Nature, 1989 - nature.com
ALZHEIMER'S disease is the most common cause of progressive intellectual failure in aged
humans. The filamentous brain lesions which define the disease occur within neurons …
humans. The filamentous brain lesions which define the disease occur within neurons …
Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
RE Tanzi, JF Gusella, PC Watkins, GAP Bruns… - Science, 1987 - science.org
The amyloid β protein has been identified as an important component of both
cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome …
cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome …
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R Sherrington, EI Rogaev, Y Liang, EA Rogaeva… - Nature, 1995 - nature.com
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …