The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …

A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …

Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …

Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …

A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …

Alzheimer's disease1 is characterized by a widespread functional disturbance of the human
brain. Fibrillar amyloid proteins are deposited inside neurons as neurofibrillary tangles2 and …

THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …

ALZHEIMER'S disease is the most common cause of progressive intellectual failure in aged
humans. The filamentous brain lesions which define the disease occur within neurons …

The amyloid β protein has been identified as an important component of both
cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome …

The amyloid proteins isolated from neuritic plaques and the cerebrovasculature of
Alzheimer's disease are self-aggregating moieties termed A4 protein1 and βprotein2, 3 …