The hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in
reproductive function by regulating the biosynthesis and secretion of the pituitary …

We have previously shown that early growth response (Egr) 1-deficient mice exhibit female
infertility, reflecting a luteinizing hormone (LH) β deficiency. Egr-1 activates the LHβ gene in …

Physiological regulation of gonadotrophin subunit gene expression was investigated in vivo
by cDNA–mRNA hybridization from individual pituitary glands from rats and mice. Common …

In this study we investigated changes in steady state cytoplasmic mRNA levels for LH
subunits in pituitaries of male rats desensitized by continuous infusion of GnRH in vivo …

We have shown previously that androgens negatively regulate LH α and β-subunit mRNA
levels, but have little or no effect on FSHβ mRNA levels in rats in vivo. In contrast, estrogen …

Recent in vivo and in vitro studies have implicated the orphan nuclear receptor,
steroidogenic factor-1 (SF-1), and the early growth response protein 1 (Egr-1) in the …

The gonadal steroids, along with gonadotropin-releasing hormone (GnRH) are involved in
the regulation of gonadotropin (GtH) production in vertebrates. Goldfish have an annual …

Akt/protein kinase B (Akt/PKB), which is activated by phosphatidylinositol-3 kinase (PI3-
kinase), plays an important role in cell survival and cell proliferation. Using the well …

Gonadotropin-releasing hormone (GnRH) stimulates gonadotropin (GTH) subunit gene
expression via G protein-coupled membrane receptors. GnRH-stimulated GTH subunit gene …

To investigate the relationship between gonadotroph function and ultrastructure, we have
compared, in parallel in female mice, the effects of several different mutations that perturb …