In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils
from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain …

Macrophages play a crucial role in recognition and phagocytosis of pathogens and in the
induction of response, immunity and immunopathology. A key strategy employed by …

Yersinia pestis is the causative agent of plague, a disease that can manifest as either
bubonic or pneumonic plague. An interesting feature of plague is that it is a rapidly …

Background Yersinia pestis causes severe disease in natural rodent hosts, but mild to
inapparent disease in certain rodent predators such as dogs. Y. pestis initiates infection in …

Various types of animal models of plague have been developed, including mice, rats,
guinea pigs, and nonhuman primates. Studies have indicated that rodent and nonhuman …

Lipopolysaccharide (LPS) extracted from eight strains of Yersinia pestis, which had been
cultured at 28 or 37° C, reacted equally well, in Western blots, with four monoclonal …

Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis.
In this study, we analyzed the population genetic structure of Y. pestis and the two other …

Despite the importance of pneumonic plague, little is known of the early pulmonary immune
responses that occur following inhalation of Yersinia pestis. Therefore, we conducted …

Yersinia pestis is a Gram-negative bacterium, and the causative agent of bubonic plague
and pneumonic plague. Because of its potential use as a biological warfare weapon, the …

The mammalian immune system comprises multiple physical, chemical, and cellular
components that are traditionally classified as innate and adaptive immunity. The innate …