The genus Yersinia consists of 15 species (www. bacterio. cict. fr/xz/yersinia. html), and only
three of them, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, are pathogenic to …

We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

Yersinia pestis KIM5 was found to be cytotoxic for the IC21 and P388D1 mouse macrophage
cell lines, as well as for resident peritoneal macrophages from C57BL/6 mice. Affected cells …

Yersinia pestis, the causative agent of plague, has been well studied at the molecular and
genetic levels, but little is known about the role that host genes play in combating this highly …

Athymic mice, deficient in mature T-lymphocytes, were killed when subcutaneously
challenged with 100 organisms of a highly virulent strain of Yersinia pestis. None of the …

Cultured mouse resident peritoneal macrophages were challenged with strains of Yersinia
pestis differing only with respect to the absence of one or more of the virulence determinants …

Pathogenic Yersinia species utilize a type III secretion system to translocate Yop effectors
into infected host cells. Yop effectors inhibit innate immune responses in infected …

Our previous study has demonstrated that Yersinia pestis Microtus 201 is a low virulent
strain to the Chinese-origin rhesus macaques, Macaca mulatta, and can protect it against …

The transformation of the enteropathogenic bacterium Yersinia pseudotuberculosis into the
plague bacillus, Yersinia pestis, has been accompanied by extensive genetic loss. This …

Yersinia pestis is a typical zoonotic bacterial pathogen. The following reasons make this
pathogen a model for studying zoonotic pathogens:(1) Its unique lifestyle makes Y. pestis an …