Neurons of the neocortex are organized into six radial layers, which have appeared at
different times during evolution, with the superficial layers representing a more recent …

Pioneering work indicates that the final position of neurons in specific layers of the
mammalian cerebral cortex is determined primarily by birthdate. Glutamatergic projection …

The arealization of the mammalian cortex is believed to be controlled by a combination of
intrinsic factors that are expressed in the cortex, and external signals, some of which are …

Adult neocortical areas are characterized by marked differences in cytoarchitecture and
connectivity that underlie their functional roles. The molecular determinants of these …

While progenitor-restricted factors broadly specify area identities in developing neocortex,
the downstream regulatory elements involved in acquisition of those identities in postmitotic …

The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and
the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a …

The generation of a precise number of neural cells and the determination of their laminar
fate are tightly controlled processes during development of the cerebral cortex. Using …

The formation of a functionally integrated nervous system is dependent on a highly
organized sequence of events that includes timely division and differentiation of progenitors …

In rodent ventral telencephalon, diffusible morphogens induce expression of the proneural
transcription factor ASCL1, which in turn induces expression of the transcription factor DLX2 …

The generation and maintenance of a plethora of neuronal subtypes is essential for normal
brain function. Nevertheless, little is known about the molecular mechanisms that maintain …