Caspases, a family of cysteinyl aspartate-specific proteases, are central mediators of
apoptotic and inflammatory pathways. Caspases are synthesized as zymogens with a …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of
apoptotic cell death and in regulating inflammation. This article focuses primarily on the …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Recent studies have established that members of the caspase protease family are essential
components of a conserved cell death program. Insights into their biological roles, structure …

Caspases are the central mediators of normal and pathological apoptotic death. They are
cysteine proteases that cleave after aspartic acid. The inactive pro-enzymes are …

Caspases are a conserved family of cysteine proteases. They play diverse roles in
inflammatory responses and apoptotic pathways. Among the caspases is a subgroup whose …

Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …

The process of apoptosis, or programmed cell death, is fundamental during normal
development and homeostasis and aberrant apoptosis has been implicated in a number of …

Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last
decade, major progress has been made to further understand caspase structure and …