It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown
to act on a wide range of histones and non-histone substrates. Numerous studies have …

Endotoxin is a potent inducer of systemic inflammatory responses in human and rodents.
Here, we show that in vivo endotoxin triggers a rapid and transient decline in ATP …

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to
contribute to age-related diseases. Although aging-associated immune dysfunction, or …

Several recent studies have suggested seemingly contrasting roles of SIRT2 in
inflammation: Our previous cell culture study has indicated that SIRT2 siRNA-produced …

Tissue fibrosis is a major cause of organ dysfunction during chronic diseases and aging. A
critical step in this process is transforming growth factor β1 (TGF-β1)-mediated …

Abstract SIRT1 (silent information regulator 1), a conserved NAD+-dependent histone
deacetylase, is closely related with various biological processes. Moreover, the important …

The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, a
multiprotein complex, triggers caspase-1 activation and maturation of the proinflammatory …

Objective—Calorie restriction (CR) prolongs the lifespan of various species, ranging from
yeasts to mice. In yeast, CR extends the lifespan by increasing the activity of silencing …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …