Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …

Microphysiological systems (MPS), which include engineered organoids (EOs), single
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …

The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …

Although basic scientific research has generated methodological and technical innovations
rapidly in recent decades, translational science has not kept pace. 1, 2 Among the factors …

An emerging area of interest for drug development over the last 13 years has been
constructing human biomimetic systems by combining the techniques of microfabrication …

Microphysiological systems, including organoids, 3-D printed tissue constructs, and organ-
on-a-chip systems (organ chips), are physiologically relevant in vitro models and have …

Purpose Microphysiological systems (MPS), also known as “organs-on-chips” or “tissue
chips,” leverage recent advances in cell biology, tissue engineering, and microfabrication to …

Microscale engineering technologies provide unprecedented opportunities to create cell
culture microenvironments that go beyond current three-dimensional in vitro models by …

Recent advances in integrating microengineering and tissue engineering have generated
promising microengineered physiological models for experimental medicine and …

Traditional cell culture and animal models utilized for preclinical drug screening have led to
high attrition rates of drug candidates in clinical trials due to their low predictive power for …