A major problem in the analysis of clinical trials is missing data caused by patients dropping
out of the study before completion. This problem can result in biased treatment comparisons …

Missing data in clinical trials are inevitable. We highlight the ICH guidelines and CPMP
points to consider on missing data. Specifically, we outline how we should consider missing …

For a variety of reasons including poorly designed case report forms (CRFs), incomplete or
invalid CRF data entries, and premature treatment or study discontinuations, missing data is …

The aim of this review was to establish the frequency with which trials take into account
missingness, and to discover what methods trialists use for adjustment in randomised …

This book provides practical guidance for statisticians, clinicians, and researchers involved
in clinical trials in the biopharmaceutical industry, medical and public health organisations …

Background: Longitudinal clinical trial has measurements at successive occasions, and
unavailability of patient at a scheduled visit causes missingness in expected full sequence of …

Background Missing data may seriously compromise inferences from randomised clinical
trials, especially if missing data are not handled appropriately. The potential bias due to …

Abstract The Points to Consider Document on Missing Data was adopted by the Committee
of Health and Medicinal Products (CHMP) in December 2001. In September 2007 the CHMP …

One of the major problems in the analysis of clinical trials is missing data caused by patients
dropping out before study completion. The issue of missing data can result in biased …

The problem of handling missing data in clinical trials is discussed, particularly in the light of
two recent publications associated with the US and European regulators. The importance of …