Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development

A Ssemaganda, LM Low, KR Verhoeft, M Wambuzi… - Metallomics, 2018 - academic.oup.com
Here, the anti-malarial activity of two gold (i) phosphine compounds auranofin and [Au
(d2pype) 2] Cl (where d2pype is 1, 2-bis (di-2-pyridylphosphino) ethane), were examined to …

Novel metalloantimalarials: Transmission blocking effects of water soluble Cu (I), Ag (I) and Au (I) phosphane complexes on the murine malaria parasite Plasmodium …

S Tapanelli, A Habluetzel, M Pellei, L Marchiò… - Journal of Inorganic …, 2017 - Elsevier
The water soluble phosphane complexes [M (L) 4] PF 6 (M= Cu (I), Ag (I)) and [Au (L) 4] Cl
(L= thp (tris (hydroxymethyl) phosphane) or PTA (1, 3, 5-triaza-7-phosphaadamantane)) …

An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite

GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …

[HTML][HTML] Gold (I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

K Fourmy, M Gouygou… - Comptes …, 2017 - comptes-rendus.academie-sciences …
A series of gold (I)-monophosphole complexes have been synthesized and characterized.
The introduction of a nitrogen moiety in the complex structure was envisioned either by …

Novel gold(i) phosphine compounds inhibit HIV-1 enzymes

P Fonteh, D Meyer - Metallomics, 2009 - academic.oup.com
The increasing incidence of human immunodeficiency virus (HIV) infection and the
associated acquired immune deficiency syndrome (AIDS) mortality rates as well as the …

Evaluation of ferrocenyl phosphines as potent antimalarials targeting the digestive vacuole function of Plasmodium falciparum

G Subramanian, A Sadeer, K Mukherjee, T Kojima… - Dalton …, 2019 - pubs.rsc.org
Owing to their lipophilic nature and chemical stability, ferrocene and its derivatives have
been widely explored as antimicrobial agents, in combination with other active chemical 'war …

A Novel hybrid of chloroquine and primaquine linked by Gold (I): Multitarget and multiphase antiplasmodial agent

C de Souza Pereira, H Costa Quadros… - …, 2021 - Wiley Online Library
Plasmodium parasites kill 435 000 people around the world every year due to unavailable
vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical …

Hybrid gold (I) NHC-artemether complexes to target falciparum malaria parasites

M Ouji, G Barnoin, Á Fernández Álvarez, JM Augereau… - Molecules, 2020 - mdpi.com
The emergence of Plasmodium falciparum parasites, responsible for malaria disease,
resistant to antiplasmodial drugs including the artemisinins, represents a major threat to …

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro

N Micale, MA Cinellu, L Maiore, AR Sannella… - Journal of inorganic …, 2011 - Elsevier
A number of structurally diverse gold compounds were evaluated as possible inhibitors of
Falcipain 2 (Fp2), a cysteine protease from P. falciparum that is a validated target for the …

Gold nanoparticles–against parasites and insect vectors

G Benelli - Acta Tropica, 2018 - Elsevier
Nanomaterials are currently considered for many biological, biomedical and environmental
purposes, due to their outstanding physical and chemical properties. The synthesis of gold …