Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of
camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic …

Delivering traditional DNA-damaging anticancer drugs into mitochondria to damage
mitochondria is a promising chemotherapy strategy. The impermeability of this mitochondrial …

Mitochondria are involved in various stages of cancer cell diffusion and metastasis.
Therefore, targeting tumor mitochondria with antineoplastic medicines to cause …

Mitochondria-targeting cancer therapies have achieved unprecedented advances attributed
to their superior ability for improving drug delivery efficiency and producing an enhanced …

Primary tumor metastasis remains to be a tough obstacle for clinical breast cancer treatment.
Since evidences have shown that mitochondria play a crucial role in tumor metastasis, we …

This Special Issue,“Strategies to Enhance Drug Permeability across Biological Barriers”, is
hosted by Pharmaceutics and highlights the recent technological advancements for …

Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising
strategy to improve the antitumor efficiency of chemotherapeutics. However, the …

Cancer metastasis, which increases the mortality in a short period of time, has been
considered as the main challenge in tumor treatment. However, tumor growth suppression …

Multidrug resistance (MDR) is thought to be the major obstacle leading to the failure of
paclitaxel (PTX) chemotherapy. To solve this problem, a glucose transporter-mediated and …

Aim: The objective of this study was to develop a mitochondria-targeted anticancer drug,
docetaxel (DTX), for chemotherapy. Materials & methods: The DTX was conjugated to 4 …