[HTML][HTML] 5-Oxo-hexahydroquinoline derivatives and their tetrahydroquinoline counterparts as multidrug resistance reversal agents
O Shahraki, M Khoshneviszadeh, M Dehghani… - Molecules, 2020 - mdpi.com
Cancer is a leading cause of death worldwide. Multidrug resistance (MDR) is a main reason
of chemotherapy failure in many patients and is often related to overexpression of ATP …
of chemotherapy failure in many patients and is often related to overexpression of ATP …
5-Oxohexahydroquinolines bearing 4-pyridyl methyl carboxylate as P-glycoprotein inhibitors and multidrug resistance reversal agents in cancer cells
S Ranjbar, FF Lashkarian, M Khoshneviszadeh… - Journal of Molecular …, 2023 - Elsevier
Multidrug resistance (MDR) limits the therapeutic effect of conventional chemotherapeutic
agents as well as novel targeted anticancer drugs. An important mechanism of MDR is the …
agents as well as novel targeted anticancer drugs. An important mechanism of MDR is the …
5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells
Multidrug resistance (MDR) in cancer cells is often associated with overexpression of ATP-
binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug …
binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug …
Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics …
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …
Overcoming multidrug resistance in human lung cancer with novel benzo [a] quinolizin-4-ones
Y Kanintronkul, R Worayuthakarn, N Thasana… - Anticancer …, 2011 - ar.iiarjournals.org
Aim: To investigate the ability of synthetic benzo [a] quinolizin-4-one derivatives to reverse
multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with …
multidrug resistance (MDR) in lung cancer cells. Materials and Methods: A cell line with …
Discovery of (quinazolin-6-yl) benzamide derivatives containing a 6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline moiety as potent reversal agents against P …
W Xue, K Liu, T Zhang, G Dong, J Wang, J Wang… - European Journal of …, 2024 - Elsevier
Abstract P-glycoprotein (P-gp) is an important factor leading to multidrug resistance (MDR)
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …
Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer
Y Li, H Zhang, W Huang, Y Li - Bioorganic & medicinal chemistry letters, 2008 - Elsevier
Exploration for new MDR-modulator utilizing tetrahydroisoquinoline as scaffold disclosed 6,
7-dimethoxy-1-(3, 4-dimethoxy) benzyl-2-(Nn-octyl-N′-cyano) guanyl-1, 2, 3, 4 …
7-dimethoxy-1-(3, 4-dimethoxy) benzyl-2-(Nn-octyl-N′-cyano) guanyl-1, 2, 3, 4 …
[HTML][HTML] Development of a novel quinoline derivative as a P-glycoprotein inhibitor to reverse multidrug resistance in cancer cells
Multidrug resistance (MDR) is one of conventional cancer chemotherapy's limitations. Our
group previously synthesized a series of quinoline-based compounds in an attempt to …
group previously synthesized a series of quinoline-based compounds in an attempt to …
Reversal effect of substituted 1, 3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells
L Sun, X Li, Y Cheng, H Yuan, M Chen, W Tang… - Biomedicine & …, 2009 - Elsevier
QA1 and QA3 are the derivatives of substituted 1, 3-dimethyl-1H-quinoxalin-2-ones that may
selectively antagonize P-glycoprotein (P-gp) in multidrug resistance (MDR) cancer cells …
selectively antagonize P-glycoprotein (P-gp) in multidrug resistance (MDR) cancer cells …
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors
Y Gao, W Shi, J Cui, C Liu, X Bi, Z Li, W Huang… - Bioorganic & Medicinal …, 2018 - Elsevier
Multidrug resistance (MDR) is one of the main obstacles of clinical chemotherapy. A great
deal of research shows that the occurrence of drug resistance in various malignant tumors is …
deal of research shows that the occurrence of drug resistance in various malignant tumors is …