Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives …
Q Qiu, B Liu, J Cui, Z Li, X Deng, H Qiang… - Journal of Medicinal …, 2017 - ACS Publications
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a principal obstacle for
successful cancer chemotherapy. A novel P-gp inhibitor with a quinazoline scaffold, 12k …
successful cancer chemotherapy. A novel P-gp inhibitor with a quinazoline scaffold, 12k …
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan …
S Jimenez-Alonso, AL Perez-Lomas… - Journal of medicinal …, 2008 - ACS Publications
We have synthesized a set of bis-pyranobenzoquinones through a direct and highly efficient
approach based on a double intramolecular domino Knoevenagel hetero Diels− Alder …
approach based on a double intramolecular domino Knoevenagel hetero Diels− Alder …
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073
W Sato, N Fukazawa, T Suzuki, K Yusa, T Tsuruo - Cancer research, 1991 - AACR
Newly synthesized quinoline derivatives were investigated for their efficacy to reverse
multidrug resistance (MDR). In this study, one of the most effective quinoline derivatives, MS …
multidrug resistance (MDR). In this study, one of the most effective quinoline derivatives, MS …
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators
W Klinkhammer, H Müller, C Globisch, IK Pajeva… - Bioorganic & medicinal …, 2009 - Elsevier
The development of new modulators possessing high efficacy, low toxicity and high
selectivity is a pivotal approach to overcoming P-glycoprotein (P-gp) mediated multidrug …
selectivity is a pivotal approach to overcoming P-glycoprotein (P-gp) mediated multidrug …
Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells
JS Koo, WC Choi, YH Rhee, HJ Lee, EO Lee, KS Ahn… - Life sciences, 2008 - Elsevier
AIMS: The resistance to chemotherapeutic drugs is a major problem for successful cancer
treatment. Multidrug resistance (MDR) phenotype is characterized by over-expression of P …
treatment. Multidrug resistance (MDR) phenotype is characterized by over-expression of P …
Synthesis and primary evaluation of quinoxalinone derivatives as potent modulators of multidrug resistance
H Yuan, X Li, X Qu, L Sun, W Xu, W Tang - Medicinal chemistry research, 2009 - Springer
P-glycoprotein-mediated drug efflux from cells is believed to be an important mechanism in
multidrug resistance (MDR) in cancer chemotherapy. The identification and development of …
multidrug resistance (MDR) in cancer chemotherapy. The identification and development of …
Discovery of 5-cyano-6-phenylpyrimidin derivatives containing an acylurea moiety as orally bioavailable reversal agents against P-glycoprotein-mediated mutidrug …
P-glycoprotein (ABCB1)-mediated multidrug resistance (MDR) has become a major obstacle
in successful cancer chemotherapy, which attracted much effort to develop clinically useful …
in successful cancer chemotherapy, which attracted much effort to develop clinically useful …
Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer
Y Li, HB Zhang, WL Huang, X Zhen, YM Li - Chinese Chemical Letters, 2008 - Elsevier
Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug
resistance reversal agents in cancer - ScienceDirect Skip to main contentSkip to article Elsevier …
resistance reversal agents in cancer - ScienceDirect Skip to main contentSkip to article Elsevier …
Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo
W Fang, Y Li, Y Cai, K Kang, F Yan… - Journal of Pharmacy …, 2007 - academic.oup.com
Abstract P-glycoprotein (P-gp) mediated multidrug resistance (MDR) is one of the main
obstacles in tumour chemotherapy. A promising approach to reverse MDR is the combined …
obstacles in tumour chemotherapy. A promising approach to reverse MDR is the combined …
Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2, 4‐Substituted Quinazoline Derivatives
L Braconi, E Teodori, M Contino, C Riganti… - …, 2022 - Wiley Online Library
Abstract Some 2, 4‐disubstituted quinazolines were synthesized and studied as multidrug
resistance (MDR) reversers. The new derivatives carried the quinazoline‐4‐amine scaffold …
resistance (MDR) reversers. The new derivatives carried the quinazoline‐4‐amine scaffold …