A series of 2-aminodihydroquinoline analogs were synthesized and their in vitro
cytotoxicities against metastatic breast adenocarcinoma cell line MDA-MB-231 were tested …

A series of dihydrobenzopyrans and tetrahydroquinolines was synthesized and
pharmacologically tested for their ability to inhibit P-glycoprotein mediated daunomycin …

Multidrug resistance (MDR) in cancer cells can lead to chemotherapeutic failure. The lack of
effective therapies has created a growing need for developing new and effective …

Multidrug resistance (MDR) is one of important issues to cause the chemotherapy failure
against cancers including gynecological malignancies. Despite some MDR reversal …

Aim: Enamino 3-benzazecine compounds, incorporating the C6-C8 allene system, were
synthesized and evaluated in vitro as inhibitors of P-glycoprotein (P-gp) and/or multidrug …

The resistance to chemotherapy of cancer cells is mediated by the overexpression of P-
glycoprotein, as an ATP-dependent membrane efflux pump. Two families of compounds …

Purpose Novel multidrug resistance (mdr) modulators have been proved as inhibitors of P-
glycoprotein (P-gp). We first investigated the in vitro effects of selected compounds in human …

The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …

Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer
cells to chemotherapeutic drugs that are characterized by different chemical structure and …

Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy
failure in cancer treatment, and it generally results from expression of ATP-dependent efflux …