Multidrug resistance in cancer mediated by the efflux pump P-glycoprotein is seriously
hindering the cancer chemotherapy. Many selective and potent compounds of P-gp …

The phytochemical study of Pedilanthus tithymaloides led to the isolation of 13 jatrophane
diterpenoids (1–13), of which eight (1–8) are new. Subsequent structural modification of the …

Over the past two decades, a number of chemical entities have been investigated in the
continuing quest to reverse P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in …

As a continuation of previous research on a new series of potent and efficacious P-gp-
dependent multidrug resistant (MDR) reversers with a N, N-bis (cyclohexanol) amine …

A series of derivatives were synthesized and studied with the aim to investigate the structure–
activity relationships of the two P‐glycoprotein (P‐gp) modulators elacridar and tariquidar …

Background The failure of conventional cancer chemotherapy has been linked to
overexpression of a membrane associated P-glycoprotein (P-gp) that acts as an energy …

Multidrug resistance (MDR) in cancer caused due to overexpression of ABC drug
transporters is a major problem in modern chemotherapy. Molecular investigations on MDR …

Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat
cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug …

Multidrug resistance (MDR) mediated by P-glycoprotein is one of the best characterized
transporter-mediated barriers to successful cancer chemotherapy. In an attempt to find MDR …

Targeting P-glycoprotein (P-gp, ABCB1 transporter), which plays an essential role in multi-
drug resistance (MDR) in cancers, with new cytotoxic agents is a promising strategy in …