Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
WW Luo, Z Tong, P Cao, FB Wang, Y Liu… - Nature …, 2022 - nature.com
Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates
innate immune responses via the adaptor protein STING. It remains unresolved how the …
innate immune responses via the adaptor protein STING. It remains unresolved how the …
Ubiquitination of STING at lysine 224 controls IRF3 activation
G Ni, H Konno, GN Barber - Science immunology, 2017 - science.org
Cytosolic DNA species derived from invading microbes or leaked from the nuclear or
mitochondrial compartments of the cell can trigger the induction of host defense genes by …
mitochondrial compartments of the cell can trigger the induction of host defense genes by …
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
H Ishikawa, Z Ma, GN Barber - Nature, 2009 - nature.com
The innate immune system is critical for the early detection of invading pathogens and for
initiating cellular host defence countermeasures, which include the production of type I …
initiating cellular host defence countermeasures, which include the production of type I …
[HTML][HTML] Regulation of STING activity in DNA sensing by ISG15 modification
Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …
[HTML][HTML] Balancing STING in antimicrobial defense and autoinflammation
SL Landman, ME Ressing, AG van der Veen - Cytokine & Growth Factor …, 2020 - Elsevier
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate
immune receptors survey the intracellular and extracellular environment for signs of a …
immune receptors survey the intracellular and extracellular environment for signs of a …
Molecular and spatial mechanisms governing STING signalling
KR Balka, D De Nardo - The FEBS Journal, 2021 - Wiley Online Library
Detection of microbial nucleic acids via innate immune receptors is critical for establishing
host defence against pathogens. The DNA‐sensing cGAS‐STING pathway has gained …
host defence against pathogens. The DNA‐sensing cGAS‐STING pathway has gained …
[HTML][HTML] The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease
H Konno, GN Barber - Microbes and infection, 2014 - Elsevier
The innate immune system is critically important for the primary sensing of invading
pathogens. Over the past decade, the cellular sensors important for recognizing microbial …
pathogens. Over the past decade, the cellular sensors important for recognizing microbial …
A cGAS-independent STING/IRF7 pathway mediates the immunogenicity of DNA vaccines
JJ Suschak, S Wang, KA Fitzgerald… - The Journal of …, 2016 - journals.aai.org
It has been known since the discovery of DNA vaccines> 20 y ago that DNA vaccines can
function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of …
function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of …
Interferon induction by STING requires its translocation to the late endosomes
To combat microbial infections, mammalian cells use a variety of innate immune response
pathways to induce synthesis of anti‐microbial proteins. The cGAS/STING pathway …
pathways to induce synthesis of anti‐microbial proteins. The cGAS/STING pathway …
STING agonism turns human T cells into interferon‐producing cells but impedes their functionality
Abstract The cGAS‐STING (cyclic GMP‐AMP synthase‐stimulator of interferon genes) axis is
the predominant DNA sensing system in cells of the innate immune system. However …
the predominant DNA sensing system in cells of the innate immune system. However …