Biotechnological production of alpha-keto acids: current status and perspectives

Y Song, J Li, H Shin, L Liu, G Du, J Chen - Bioresource technology, 2016 - Elsevier
Abstract Alpha-keto (α-keto) acids are used widely in feeds, food additives, pharmaceuticals,
and in chemical synthesis processes. Although most α-keto acids are currently produced by …

Comparative analysis of the chemical and biochemical synthesis of keto acids

Z Luo, S Yu, W Zeng, J Zhou - Biotechnology advances, 2021 - Elsevier
Keto acids are essential organic acids that are widely applied in pharmaceuticals,
cosmetics, food, beverages, and feed additives as well as chemical synthesis. Currently …

Novel pathways and products from 2-keto acids

P Jambunathan, K Zhang - Current opinion in biotechnology, 2014 - Elsevier
Highlights•The 2-ketoacid pathway has diverse chemistry.•Aliphatic alcohols and carboxylic
acids can be produced by decarboxylation and redox reactions.•Bifunctional compounds …

Overproduction and secretion of α-ketoglutaric acid by microorganisms

C Otto, V Yovkova, G Barth - Applied microbiology and biotechnology, 2011 - Springer
This mini-review presents a summary of research results of biotechnological production of
alpha-ketoglutaric acid (KGA) by bacteria and yeasts. KGA is of particular industrial interest …

[HTML][HTML] In vitro metabolic engineering for the production of α-ketoglutarate

B Beer, A Pick, V Sieber - Metabolic engineering, 2017 - Elsevier
Abstract α-Ketoglutarate (aKG) represents a central intermediate of cell metabolism. It is
used for medical treatments and as a chemical building block. Enzymatic cascade reactions …

2-Keto acids based biosynthesis pathways for renewable fuels and chemicals

Y Tashiro, GM Rodriguez… - Journal of Industrial …, 2015 - academic.oup.com
Global energy and environmental concerns have driven the development of biological
chemical production from renewable sources. Biological processes using microorganisms …

Advances in the microbial biosynthesis of methyl ketones

S Xu, Q Zhang, G Dong, Z Liu, J Fu, S Shi - Renewable and Sustainable …, 2025 - Elsevier
Methyl ketone, a fatty acid derivative, has attracted extensive attention due to its remarkable
properties such as a high cetane number, low freezing point, immiscibility with water, and …

Current advance in biological production of short-chain organic acid

L Sun, M Gong, X Lv, Z Huang, Y Gu, J Li, G Du… - Applied Microbiology …, 2020 - Springer
As natural metabolites, organic acids have been widely applied in food, pharmaceutical, and
bio-based materials industries. Particularly, the short-chain organic acids, including C2, C3 …

Simultaneous isomerization and reactive extraction of biomass sugars for high yield production of ketose sugars

B Li, P Relue, S Varanasi - Green Chemistry, 2012 - pubs.rsc.org
A desire to achieve one-pot syntheses of value-added products from biomass sugars has
led to intense research efforts to convert these sugars with high yields into their ketose …

Bio–based Pentenoic Acids as Intermediates to Higher Value‐Added Mono‐and Dicarboxylic Acids

JD Nobbs, NZB Zainal, J Tan, E Drent… - …, 2016 - Wiley Online Library
The acid catalyzed reactive distillation of γ‐valerolactone yields pentenoic acids (PEAs)
which can be obtained in> 90% purity and> 97% selectivity. The PEAs (five isomers) can be …