Solvent influence on manufacturability, phase behavior and morphology of amorphous solid dispersions prepared via bead coating
E Boel, F Giacomini, G Van den Mooter - European Journal of …, 2021 - Elsevier
Bead coating or fluid-bed coating serves as an auspicious solvent-based amorphous solid
dispersion (ASD) manufacturing technique in respect of minimization of potential physical …
dispersion (ASD) manufacturing technique in respect of minimization of potential physical …
The impact of applying an additional polymer coating on high drug-loaded amorphous solid dispersions layered onto pellets
E Boel, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of
amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study …
amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study …
[HTML][HTML] The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative Evaluation with Spray Drying
E Boel, F Reniers, W Dehaen, G Van den Mooter - Pharmaceutics, 2022 - mdpi.com
Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers
potential advantages regarding the minimization of physical stability issues, there is still a …
potential advantages regarding the minimization of physical stability issues, there is still a …
Development of a surface coating technique with predictive value for bead coating in the manufacturing of amorphous solid dispersions
E Boel, P Panini, G Van den Mooter - Pharmaceutics, 2020 - mdpi.com
The aim of this paper was to investigate whether a surface coating technique could be
developed that can predict the phase behavior of amorphous solid dispersions (ASDs) …
developed that can predict the phase behavior of amorphous solid dispersions (ASDs) …
Amorphous solid dispersions of BCS class II drugs: a rational approach to solvent and polymer selection
Miniaturised solvent casting (MSC) has been developed as a method for screening the
stability of amorphous solid dispersions (ASD) of BCS class II drugs. The aim of the work …
stability of amorphous solid dispersions (ASD) of BCS class II drugs. The aim of the work …
Inhomogeneous phase significantly reduces oral bioavailability of felodipine/PVPVA amorphous solid dispersion
D Gao, D Zhu, X Zhou, S Dong… - Molecular Pharmaceutics, 2022 - ACS Publications
Inhomogeneity is a key factor that significantly influences the dissolution behavior of
amorphous solid dispersion (ASD). However, the underlying mechanisms of the effects of …
amorphous solid dispersion (ASD). However, the underlying mechanisms of the effects of …
A review of various manufacturing approaches for developing amorphous solid dispersions
KK Konda, S Dhoppalapudi - Journal of Drug Delivery and …, 2022 - jddtonline.info
In recent years amorphous solid dispersions (ASD) has gained a tremendous response for
improving the solubility of poorly water-soluble drug substances. Despite the stability …
improving the solubility of poorly water-soluble drug substances. Despite the stability …
A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs
Fluid bed coating offers potential advantages as a formulation platform for amorphous solid
dispersions (ASDs) of poorly soluble drugs, being a one-step manufacturing process which …
dispersions (ASDs) of poorly soluble drugs, being a one-step manufacturing process which …
Navigating the Solution to Drug Formulation Problems at Research and Development Stages by Amorphous Solid Dispersion Technology.
D Tripathi, BH MP, J Sahoo, J Kumari - Recent Advances in Drug …, 2023 - europepmc.org
Amorphous Solid Dispersions (ASDs) have indeed revolutionized the pharmaceutical
industry, particularly in drug solubility enhancement. The amorphous state of a drug, which …
industry, particularly in drug solubility enhancement. The amorphous state of a drug, which …
Solvent-casted films to assist polymer selection for amorphous solid dispersions during preclinical studies: In-vitro and In-vivo Exploration
LI Mosquera-Giraldo, M Donoso, K Stefanski… - Pharmaceutical …, 2021 - Springer
Purpose The use of two solvent-casted film methods to select optimal polymer compositions
for amorphous solid dispersions prepared to support preclinical pharmacokinetic and …
for amorphous solid dispersions prepared to support preclinical pharmacokinetic and …