Amorphous solid dispersions (ASDs) may entail tailor-made dosage form design to exploit
their solubility advantage. Surface phenomena dominated the performance of amorphous …

Background: An increase in poorly water-soluble drugs makes the design of drug delivery
systems challenging. Methods: Currently, a number of prospective solid dispersions have …

Solid dispersion is one of the most effective ways to improve the dissolution of insoluble
drugs. When the carrier can highly disperse the drug, it will increase the wettability of the …

Amorphous solid dispersions are used as a strategy to improve the bioavailability of poorly
water-soluble compounds. When formulating with a polymer, it is important not only for the …

The incorporation of a counterion into an amorphous solid dispersion (ASD) has been
proven to be an attractive strategy to improve the drug dissolution rate. In this work, the …

This study investigates the effects of micro-environment modification and polymer type on
the in-vitro dissolution behavior and in-vivo performance of micro-environment pH modifying …

Historically, amorphous solid dispersion technology with polymeric carriers has been
employed to stabilize high-energy amorphous phases of poorly water-soluble drug …

Amorphous solid dispersion formulations (ASD) are increasingly being used as a
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …

Purpose Plasticizers are commonly used in the preparation of amorphous solid dispersions
(ASDs) with the main goal of aiding processability; however, to the best of our knowledge …

The objective of the current study is to mechanistically differentiate the dissolution and
supersaturation behaviors of amorphous drugs from amorphous solid dispersions (ASDs) …