Triple inhaler versus dual bronchodilator therapy in COPD: real-world effectiveness on mortality

S Suissa, S Dell'Aniello, P Ernst - COPD: Journal of Chronic …, 2022 - Taylor & Francis
Randomized trials of triple therapy including an inhaled corticosteroid (ICS) for chronic
obstructive pulmonary disease (COPD) reported remarkable benefits on mortality compared …

Triple therapy trials in COPD: a precision medicine opportunity

S Suissa, A Ariel - European Respiratory Journal, 2018 - Eur Respiratory Soc
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy document for the
treatment of chronic obstructive pulmonary disease (COPD) suggests that, after …

Triple therapy versus single and dual long-acting bronchodilator therapy in chronic obstructive pulmonary disease: a systematic review and meta-analysis

M Cazzola, P Rogliani, L Calzetta… - European Respiratory …, 2018 - Eur Respiratory Soc
We performed a meta-analysis to compare the impact of triple combination therapy with
inhaled corticosteroids (ICSs), long-acting β 2-agonists (LABAs), and long-acting muscarinic …

When is dual bronchodilation indicated in COPD?

M Thomas, DMG Halpin… - International Journal of …, 2017 - Taylor & Francis
Inhaled bronchodilator medications are central to the management of COPD and are
frequently given on a regular basis to prevent or reduce symptoms. While short-acting …

Comparative efficacy of combination bronchodilator therapies in COPD: a network meta-analysis

EL Huisman, SM Cockle, AS Ismaila… - … Journal of Chronic …, 2015 - Taylor & Francis
Background Several new fixed-dose combination bronchodilators have been recently
launched, and assessing their efficacy relative to each other, and with open dual …

Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis

Y Zheng, J Zhu, Y Liu, W Lai, C Lin, K Qiu, J Wu, W Yao - Bmj, 2018 - bmj.com
Objective To compare the rate of moderate to severe exacerbations between triple therapy
and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease …

A pooled analysis of mortality in patients with COPD receiving dual bronchodilation with and without additional inhaled corticosteroid

M Miravitlles, K Verhamme, PMA Calverley… - … journal of chronic …, 2022 - Taylor & Francis
Background Recent studies report a lower mortality rate during treatment with long-acting
muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA)/inhaled corticosteroid (ICS) …

Dual bronchodilator therapy as first-line treatment in maintenance-naïve patients with symptomatic COPD: a pre-specified analysis of the EMAX trial

L Bjermer, IH Boucot, F Maltais, EM Kerwin… - … Journal of Chronic …, 2021 - Taylor & Francis
Introduction Limited prospective evidence is available to guide selection of first-line
maintenance therapy in patients with COPD. This pre-specified analysis of the EMAX trial …

Impact of switching from triple therapy to dual bronchodilation in COPD: the DACCORD 'real world'study

CF Vogelmeier, H Worth, R Buhl, CP Criée… - Respiratory …, 2022 - Springer
Introduction Chronic obstructive pulmonary disease (COPD) guidelines recommend
reserving triple therapy of inhaled corticosteroid (ICS), long-acting β2-agonist (LABA) and …

Comparative effectiveness of triple therapy versus dual bronchodilation in COPD

J Voorham, M Corradi, A Papi… - ERJ Open …, 2019 - Eur Respiratory Soc
This real-world study compared the effectiveness of triple therapy (TT; long-acting
muscarinic antagonists (LAMAs)/long-acting inhaled β-agonists (LABAs)/inhaled …