Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind …

D Singh, A Papi, M Corradi, I Pavlišová, I Montagna… - The Lancet, 2016 - thelancet.com
Background Few data are available for the efficacy of" triple therapy" with two long-acting
bronchodilators and an inhaled corticosteroid in chronic obstructive pulmonary disease …

Triple therapy for COPD: a crude analysis from a systematic review of the evidence

JL Lopez-Campos… - Therapeutic …, 2019 - journals.sagepub.com
We systematically reviewed the current knowledge on fixed-dose triple therapies for the
treatment of chronic obstructive pulmonary disease (COPD), with a specific focus on its …

Future concepts in bronchodilation for COPD: dual-versus monotherapy

D Singh, JF Donohue, IH Boucot… - European …, 2021 - Eur Respiratory Soc
Most patients with COPD are recommended to initiate maintenance therapy with a single
long-acting bronchodilator, such as a long-acting muscarinic antagonist or long-acting β2 …

Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial

CF Vogelmeier, EM Kerwin… - Therapeutic …, 2020 - journals.sagepub.com
Rationale: Symptom relief is a key treatment goal in patients with chronic obstructive
pulmonary disease (COPD). However, there are limited data available on the response to …

Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD

C Strange, V Walker, M DePietro, J Tong… - … Journal of Chronic …, 2019 - Taylor & Francis
Background: This study compared real-world patient-reported outcomes (PROs) measured
by the Clinical COPD Questionnaire (CCQ), the London Chest Activities of Daily Living …

Canadian Thoracic Society Clinical Practice Guideline on pharmacotherapy in patients with COPD–2019 update of evidence

J Bourbeau, M Bhutani, P Hernandez, SD Aaron… - 2019 - Taylor & Francis
In this guideline update, we highlight important and new findings related to pharmacological
therapy of chronic obstructive pulmonary disease (COPD) that should change clinical …

[HTML][HTML] Once-daily single-inhaler triple versus dual therapy in patients with COPD

DA Lipson, F Barnhart, N Brealey… - … England Journal of …, 2018 - Mass Medical Soc
Background The benefits of triple therapy for chronic obstructive pulmonary disease (COPD)
with an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long …

[HTML][HTML] Comparisons of exacerbations and mortality among regular inhaled therapies for patients with stable chronic obstructive pulmonary disease: systematic …

HW Lee, J Park, J Jo, EJ Jang, CH Lee - PLoS medicine, 2019 - journals.plos.org
Background Although exacerbation and mortality are the most important clinical outcomes of
stable chronic obstructive pulmonary disease (COPD), the drug classes that are the most …

[HTML][HTML] Trends and characteristics of global initiative for chronic obstructive lung disease guidelines-discordant prescribing of triple therapy among patients with …

SP Bhatt, C Blauer-Peterson, EK Buysman… - … Diseases: Journal of …, 2022 - ncbi.nlm.nih.gov
Background: Triple therapy (long-acting muscarinic antagonist [LAMA] plus long-acting
beta2-agonist [LABA] plus inhaled corticosteroid [ICS]) is recommended by the Global …

Real-world outcomes in patients with chronic obstructive pulmonary disease initiating long-acting mono bronchodilator therapy

LGS Bengtson, M DePietro… - Therapeutic …, 2018 - journals.sagepub.com
Background: Randomized clinical trials have shown long-acting mono bronchodilator
therapy to be efficacious in improving lung function and dyspnea, while reducing …