Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms

AK Srivastava, CE Schwartz - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …

Genetic causes of developmental disorders

JAS Vorstman, RA Ophoff - Current opinion in neurology, 2013 - journals.lww.com
Similar to what is the case for intellectual disability, recent genetic studies indicate a large
degree of genetic heterogeneity for autism and ADHD. Many of the disease risk variants …

Genetics of autism: overview and new directions

P Szatmari, MB Jones, L Zwaigenbaum… - Journal of autism and …, 1998 - Springer
Genetic epidemiology is the study of inherited factors involved in the etiology of a disease or
disorder and uses the methods of both medical genetics and clinical epidemiology. In …

Clinical genetic aspects of autism spectrum disorders

GB Schaefer - International journal of molecular sciences, 2016 - mdpi.com
Early presumptions opined that autism spectrum disorder (ASD) was related to the rearing of
these children by emotionally-distant mothers. Advances in the 1960s and 1970s clearly …

Autism spectrum disorders: the quest for genetic syndromes

DI Zafeiriou, A Ververi, V Dafoulis… - American Journal of …, 2013 - Wiley Online Library
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disabilities with various etiologies, but with a heritability estimate of more than 90 …

Autism spectrum disorders: etiology and pathology

AK Sauer, J Stanton, S Hans… - Exon Publications, 2021 - exonpublications.com
Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause
of ASD is unknown, but several genetic and non-genetic risk factors have been …

Autism spectrum disorders and epigenetics

D Grafodatskaya, B Chung, P Szatmari… - Journal of the American …, 2010 - Elsevier
OBJECTIVE: Current research suggests that the causes of autism spectrum disorders (ASD)
are multifactorial and include both genetic and environmental factors. Several lines of …

Genetic research in autism spectrum disorders

EB Robinson, BM Neale, SE Hyman - Current opinion in pediatrics, 2015 - journals.lww.com
Genetic studies have the potential to identify the biological underpinnings of ASDs and other
neuropsychiatric disorders. The data they generate are already being used to examine …

Genetic and epigenetic networks in intellectual disabilities

H Van Bokhoven - Annual review of genetics, 2011 - annualreviews.org
Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …

Genetics of autism spectrum disorders

DH Geschwind - Trends in cognitive sciences, 2011 - cell.com
Characterized by a combination of abnormalities in language, social cognition and mental
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …