Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms
AK Srivastava, CE Schwartz - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …
developmental disorders present in humans. Combined, they affect between 3 and 5% of …
Genetic causes of developmental disorders
JAS Vorstman, RA Ophoff - Current opinion in neurology, 2013 - journals.lww.com
Similar to what is the case for intellectual disability, recent genetic studies indicate a large
degree of genetic heterogeneity for autism and ADHD. Many of the disease risk variants …
degree of genetic heterogeneity for autism and ADHD. Many of the disease risk variants …
Genetics of autism: overview and new directions
P Szatmari, MB Jones, L Zwaigenbaum… - Journal of autism and …, 1998 - Springer
Genetic epidemiology is the study of inherited factors involved in the etiology of a disease or
disorder and uses the methods of both medical genetics and clinical epidemiology. In …
disorder and uses the methods of both medical genetics and clinical epidemiology. In …
Clinical genetic aspects of autism spectrum disorders
GB Schaefer - International journal of molecular sciences, 2016 - mdpi.com
Early presumptions opined that autism spectrum disorder (ASD) was related to the rearing of
these children by emotionally-distant mothers. Advances in the 1960s and 1970s clearly …
these children by emotionally-distant mothers. Advances in the 1960s and 1970s clearly …
Autism spectrum disorders: the quest for genetic syndromes
DI Zafeiriou, A Ververi, V Dafoulis… - American Journal of …, 2013 - Wiley Online Library
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disabilities with various etiologies, but with a heritability estimate of more than 90 …
disabilities with various etiologies, but with a heritability estimate of more than 90 …
Autism spectrum disorders: etiology and pathology
Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause
of ASD is unknown, but several genetic and non-genetic risk factors have been …
of ASD is unknown, but several genetic and non-genetic risk factors have been …
Autism spectrum disorders and epigenetics
D Grafodatskaya, B Chung, P Szatmari… - Journal of the American …, 2010 - Elsevier
OBJECTIVE: Current research suggests that the causes of autism spectrum disorders (ASD)
are multifactorial and include both genetic and environmental factors. Several lines of …
are multifactorial and include both genetic and environmental factors. Several lines of …
Genetic research in autism spectrum disorders
Genetic studies have the potential to identify the biological underpinnings of ASDs and other
neuropsychiatric disorders. The data they generate are already being used to examine …
neuropsychiatric disorders. The data they generate are already being used to examine …
Genetic and epigenetic networks in intellectual disabilities
H Van Bokhoven - Annual review of genetics, 2011 - annualreviews.org
Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …
Genetics of autism spectrum disorders
DH Geschwind - Trends in cognitive sciences, 2011 - cell.com
Characterized by a combination of abnormalities in language, social cognition and mental
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …