"Effects of high dose of simvastatin on levels of dopamine and its reup" by How-Sung Lee,
Qing Wang et al. Home Search Browse Communities My Account About DC Network Digital …

Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin …

Sprague–Dawley rats with unilateral lesion of the medial forebrain bundle by 6-
hydroxydopamine showed marked decrease in the expression of dopamine D1 and D2 …

OBJECTIVE: The aim of this study is to investigate the antidepressant and anxiolytic effects
of simvastatin in rats. METHODS: Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats …

Simvastatin, an important member of statin family is widely prescribed as cholesterol-
lowering agent. Like other statins it acts by inhibiting the rate limiting enzyme 3-hydroxy-3 …

ABSTRACT Objective: Statins, or 3-hydroxyl-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase inhibitors, which are potent inhibitors of cholesterol synthesis, are widely used in …

Background: Simvastatin is a lipophilic statin and can cross the blood-brain barrier. The aim
of this study was to evaluate the effect of simvastatin on pyramidal cells in CA1, CA2, and …

Introduction: Simvastatin is a lipophilic statin. Lipophilic statins can cross the blood-brain
barrier. The present study investigates the effect of simvastatin on working memory and …

Objective This study aimed to investigate the antidepressant effect of simvastatin in the
hydrocortisone model of depression. Background Depression is considered the most …

The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-
glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) …