There are currently no FDA-approved medications to reduce cocaine relapse. The majority
of preclinical studies aimed at identifying the neurobiology underlying relapse involve the …

Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations
underlying cocaine seeking and to screen medications to reduce seeking. However, while …

Humans and laboratory animals remain highly vulnerable to relapse to cocaine‐seeking
after prolonged periods of withdrawal from the drug. It has been hypothesized that this …

Cocaine addiction remains without an effective pharmacotherapy and is characterized by an
inability of addicts to inhibit relapse to drug use. Vulnerability to relapse arises from an …

Cocaine addiction is characterized by compulsive drug seeking, including relapse after a
period of withdrawal. The relapse response requires increased glutamate transmission in …

Factors that result in augmented reinstatement, including increased withdrawal period
duration and high levels of cocaine consumption, may provide insight into relapse …

Rationale The beta-lactam antibiotic ceftriaxone reliably attenuates the reinstatement of
cocaine seeking. While the restoration of nucleus accumbens core (NA core) GLT-1 …

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc)
core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1) …

Decreased basal glutamate levels are observed in the rat nucleus accumbens (NA) core
following cocaine self-administration. This disruption of glutamate homeostasis arises from a …

Individuals with opioid use disorder (OUD) frequently use other substances, including
cocaine. Opioid withdrawal is associated with increased likelihood of cocaine use, which …